Meals Additive E171 Could Influence Human Well being


E171, a combination of micro- and nano-sized particles of titanium dioxide (TiO2), is usually utilized in excessive portions in meals and a few medicines as a whitening agent. Discovered in additional than 900 meals merchandise resembling chewing gum and mayonnaise, E171 is consumed in excessive proportion on a regular basis by the final inhabitants. A brand new research, carried out in mice, gives proof that TiO2 nanoparticles might have a considerable and dangerous affect on human well being.

TiO2 triggers biofilm formation by commensal bacteria: (A, B) the clustering effect of TiO2 on (A) E. coli and (B) E. faecalis in vitro was visualized by Nanolive imaging in the presence of 0, 0.5, 1, or 50 μg/ml TiO2 after 24 h incubation. False-coloring was applied to images based on refractive index, where black represents the refractive index of TiO2 and green represents bacteria. Image credit: Pinget et al, doi: 10.3389/fnut.2019.00057.

TiO2 triggers biofilm formation by commensal micro organism: (A, B) the clustering impact of TiO2 on (A) E. coli and (B) E. faecalis in vitro was visualized by Nanolive imaging within the presence of zero, zero.5, 1, or 50 μg/ml TiO2 after 24 h incubation. False-coloring was utilized to photographs based mostly on refractive index, the place black represents the refractive index of TiO2 and inexperienced represents micro organism. Picture credit score: Pinget et al, doi: 10.3389/fnut.2019.00057.

Whereas nanoparticles have been generally utilized in medicines, meals, clothes, and different purposes, the potential impacts of nanoparticles, particularly their long run results, are nonetheless poorly understood.

Consumption of TiO2 has significantly elevated within the final decade and has already been linked to a number of medical situations, and though it’s permitted in meals, there’s inadequate proof about its security.

“It’s properly established that dietary composition has an impression on physiology and well being, but the function of meals components is poorly understood,” stated Professor Wojciech Chrzanowski, a nanotoxicology knowledgeable on the College of Sydney.

“There may be growing proof that steady publicity to nanoparticles has an impression on intestine microbiota composition, and since intestine microbiota is a gate keeper of our well being, any modifications to its operate have an affect on total well being.”

“Our analysis presents pivotal proof that consumption of meals containing E171 impacts intestine microbiota in addition to irritation within the intestine, which may result in ailments resembling inflammatory bowel ailments and colorectal most cancers.”

The research confirmed that TiO2 interacts with micro organism within the intestine and impairs a few of their features which can outcome within the growth of ailments.

“This research investigated results of TiO2 on intestine well being in mice and located that TiO2 didn’t change the composition of intestine microbiota, however as a substitute it affected micro organism exercise and promoted their development in a type of undesired biofilm,” stated Dr. Laurence Macia, additionally from the College of Sydney.

“We’re saying that its consumption needs to be higher regulated by meals authorities.”

“Lastly, our work highlights the necessity for additional analysis into how TiO2, by itself and together with different meals components, impacts human well being,” the scientists stated.

“Such analysis would higher inform the regulation of meals components such TiO2 and thus probably cut back the incidence of non-communicable ailments related to the western life-style.”

The analysis was printed within the journal Frontiers in Vitamin.


Gabriela Pinget et al. Influence of the Meals Additive Titanium Dioxide (E171) on Intestine Microbiota-Host Interplay. Entrance. Nutr, printed on-line Could 14, 2019; doi: 10.3389/fnut.2019.00057

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